Benzalkonium chloride breaks down conjunctival immunological tolerance in a murine model
نویسندگان
چکیده
منابع مشابه
Autoimmunity: When self-tolerance breaks down
The spontaneous development of destructive polyarthritis in mice transgenic for an autoreactive T-cell receptor supports the notion that a failure of T-cell self-tolerance can lead to similar diseases in humans, and sheds new light on the role of peripheral tolerance in the avoidance of such pathological immune responses.
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PURPOSE Benzalkonium chloride (BAK), the most commonly used preservative in eye drops, is known to induce ocular irritation symptoms and dry eye in long-term treated patients and animal models. As tear film hyperosmolarity is diagnostic of some types of dry eye disease, we determined in vitro on conjunctival epithelial cells the cytoxicity of BAK in hyperosmolar conditions through cell viabilit...
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PURPOSE Conjunctival melanoma (CM) is an ocular malignancy with a high rate of local recurrences after treatment, and can give rise to deadly metastases. The establishment of a murine model will further our understanding of this disease and allow in vivo testing of new therapies. We therefore analyzed the ability of three CM cell lines to grow orthotopically and spread to distant sites. Further...
متن کاملEffects of benzalkonium chloride on growth and survival of Chang conjunctival cells.
PURPOSE The aim of this study was to investigate the action of benzalkonium chloride (BAC), used as a preservative in most ophthalmic topical solutions, on epithelial conjunctival cells in vitro. METHODS A continuous human conjunctival cell line (Wong-Kilbourne derivative of Chang conjunctiva) was exposed to BAC solutions at various concentrations (0.1%-0.0001%) during a period of 10 minutes....
متن کاملDifferential mechanisms of conjunctival cell death induction by ultraviolet irradiation and benzalkonium chloride.
PURPOSE To determine the molecular mechanisms of conjunctival cell death on exposure to the quaternary ammonium preservative benzalkonium chloride (BAC) and ultraviolet (UV) irradiation. METHODS Chang conjunctival cells, either wild-type or stably transfected with various constructs encoding antiapoptotic molecules or transiently transfected with siRNA targeting the beclin-1 gene, were expose...
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ژورنال
عنوان ژورنال: Mucosal Immunology
سال: 2012
ISSN: 1933-0219,1935-3456
DOI: 10.1038/mi.2012.44